Publication details

Effect of methamphetamine and fluoxetine combination on behavioural activity in wistar albino rats

Authors

DOSTÁLEK Miroslav PISTOVČÁKOVÁ Jana SLÍVA Jiří HADAŠOVÁ Eva

Year of publication 2002
Type Article in Periodical
Magazine / Source Bratislavské lekárské listy
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.bmj.cz
Field Pharmacology and pharmaceutical chemistry
Keywords fluoxetine; methamphetamine; behaviour; rat
Description Locomotor / exploratory behavioural changes were followed in Wistar rats pretreated with methamphetamine, fluoxetine or their combination. An "open field" (Acti-track, Panlab, Spain) was used as the tracking arena. Methamphetamine significantly increased all measured behavioural parameters while fluoxetine showed inhibitory effects. Pretreatment with combination of these drugs resulted in a more profound inhibition of locomotor activity than in fluoxetine given alone.
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