Publication details
Trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines: Chiral recognition and Transformations
| Authors | |
|---|---|
| Year of publication | 2002 |
| Type | Article in Proceedings |
| Conference | Book of Abstracts from the 14th International Symposium on Chirality |
| MU Faculty or unit | |
| Citation | |
| Field | Organic chemistry |
| Keywords | chiral recognition; microwave irradiation; racemization; |
| Description | The title compounds 2 (Z = OH, Cl, Br, OCH3, mesyl, tosyl, 3,4-(methylenedioxy)phenoxy) are synthetic precursors of an antidepressive drug paroxetine 1 [1]. Chiral recognition of 2 was observed by NMR spectroscopy in the presence of (S)-Mosher acid 5. For most substrates in the series, the non-equivalence induced in their 1H and 19F NMR spectra was sufficiently large to allow the evaluation of enantiomeric purity [2]. |
| Related projects: |