Informace o publikaci
Trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines: Chiral recognition and Transformations
| Autoři | |
|---|---|
| Rok publikování | 2002 |
| Druh | Článek ve sborníku |
| Konference | Book of Abstracts from the 14th International Symposium on Chirality |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Organická chemie |
| Klíčová slova | chiral recognition; microwave irradiation; racemization; |
| Popis | The title compounds 2 (Z = OH, Cl, Br, OCH3, mesyl, tosyl, 3,4-(methylenedioxy)phenoxy) are synthetic precursors of an antidepressive drug paroxetine 1 [1]. Chiral recognition of 2 was observed by NMR spectroscopy in the presence of (S)-Mosher acid 5. For most substrates in the series, the non-equivalence induced in their 1H and 19F NMR spectra was sufficiently large to allow the evaluation of enantiomeric purity [2]. |
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