Publication details

Neuronal nitric oxide synthase (NOS1) gene polymorphism and IgE-mediated allergy in the Central European population

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Authors

IZAKOVIČOVÁ HOLLÁ Lydie SCHÜLLER Marcel BUČKOVÁ Dana VÁCHA Jiří

Year of publication 2004
Type Article in Periodical
Magazine / Source Allergy
MU Faculty or unit

Faculty of Medicine

Citation
Field Genetics and molecular biology
Keywords IgE; gene; polymorphism; allergy; NOS; nitric oxide
Description Several findings suggest that nitric oxide (NO) plays a significant role in the regulation of the Th1/Th2 balance and contributes to the development of allergic diseases. Our study investigates a possible association of C/T transition located 276-bp downstream from the translation termination site in exon 29 of the human NOS1 gene with IgE-mediated allergic diseases in the Czech population.
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