Publication details

ICOS deficiency in patients with common variable immunodeficiency

Authors

SALZER Ulrich MAUL-PAVICIC Andrea CUNNINGHMA-RUNDLES Charlotte URSCHEL Simon BELOHRADSKY Berd LITZMAN Jiří HOLM Are FRANCO José Luis PLEBANI Alessandro HAMMARSTROM Lennart SKRABL Andrea SCHWINGER Wolfgang GRIMBACHER Bodo

Year of publication 2004
Type Article in Periodical
Magazine / Source Clin Immunol
MU Faculty or unit

Faculty of Medicine

Citation
Field Immunology
Keywords CVID; ICOS; Immunodeficiency
Description Common variable immunodeficiency (CVID) is the most frequent clinically significant primary antibody deficiency in man, predisposing to recurrent bacterial infections. Recently, we showed that the homozygous loss of the inducible costimulator (ICOS) on activated T cells may result in an adult onset form of CVID with autosomal recessive inheritance (AR-CVID). We screened 181 sporadic CVID patients and 13 CVID patients from nine families with AR-CVID for mutations in ICOS by genomic DNA sequencing. In the AR-CVID families, the genomic integrity of the ligand for ICOS (ICOS-L) was also evaluated. In two of the nine AR-CVID families, we identified five individuals with ICOS deficiency, carrying the identical large genomic deletion of ICOS as previously described. In the remaining seven AR-CVID families, we subsequently sequenced the coding region of the ICOS ligand but found no mutations. The incidence of ICOS deficiency among patients with CVID is less than 5%. Worldwide, there are now a total of nine patients diagnosed with ICOS deficiency most likely due to a common founder. ICOS-L deficiency could not be identified in families with AR-CVID

You are running an old browser version. We recommend updating your browser to its latest version.

More info