Involvement of cannabinoid CB1 and CB2 receptor activity in the development of behavioural sensitization to methamphetamine effects in mice

• Authors: LANDA Leoš; ŠLAIS Karel; ŠULCOVÁ Alexandra
• Year of publication: 2006
• Type: Article in Periodical
• Magazine / Source: Neuroendocrinology Letters
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: methamphetamine; cannabinoids; behavioural sensitization; locomotion; mice
• Description: Methamphetamine produced significant sensitization to its stimulatory effect on locomotion. Methanandamide pre-treatment elicited cross-sensitization to methamphetamine effect, whereas pre-treatment with JWH 015 did not. Combined pre-treatment with methamphetamine+AM 251 suppressed sensitization to methamphetamine.

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