Publication details
Effect of haloperidol on transient outward potassium current in rat ventricular myocytes
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | European Journal of Pharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | haloperidol; transient outward current; sigma receptors; rat ventricular myocytes; whole-cell pach clamp; quantitative model |
| Description | Haloperidol induced a decrease of amplitude and an acceleration of apparent inactivation of transient outward potassium current (Ito), both in a voltage-dependent manner. The averaged inhibition of Ito, evaluated as a change of its time integral, was 23.0 +/- 3.2% at stimulation frequency of 0.1 Hz. As a consequence of slow recovery of Ito from the haloperidol-induced block (time constant 1482 +/- 83 ms), a cumulation of the block up to about 40% appeared at 3.3 Hz. |
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