Publication details
Vybrané aplikace technologie cDNA microarrays v onkologickém výzkumu
| Title in English | Selected applications of cDNA microarrays technology in oncological research |
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| Authors | |
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Klinická onkologie |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | microarrays; leukemia; colon cancer; ex vivo diferentiation |
| Description | In this paper we bring a scientific review of studies in which cDNA microarrays technology allowed us to create new insights into malignant transformation processes. We can monitor parallel expression activity of thousands of genes using this technology. Using appropriate tools we can evaluate biological correlations that were practically impossible few years ago. We have developed new tools and techniques transforming the data into form suitable for oncological research. Special visualizations are necessary for some types of studies. E.g. transcription maps are proper tool for studying activity of chromosomal regions. We have implemented our own software for TM generating. On the basis of combination of its outputs and actual knowledge we have formulated our conclusions. Using intuitive TM extensions we have obtained many useful visualizations e.g. density of active genes, cumulative expression etc. These tools are supposed to help clinicians while forming diagnoses of malignant diseases and while treatment planning. Keywords: microarrays, leukemia, colorectal carcinoma, ex vivo differentiation |
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