Publication details
Development of neurogenic and myogenic conditions in critical illness neuromuscular disorders: follow-up histopathological study
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Neuromuscular Disorders |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | Critical illness; polyneuropathy; myopathy; histopatological findings |
| Description | Histopathological analysis of 52 biopsies from 43 adult critically ill patients was focused on the course of critically ill patients with intensive care polyneuropathy (ICP) or myopathy (ICM). Needle or open biopsies were processed using a set of conventional histological and histochemical methods. The results were compared with neurophysiologic findings and the clinical state of the patients. ICM and ICP develop soon after the beginning of the disease. The longest interval between the onset of the disease and findings of necrotizing myopathy (MN) was 6 weeks (42 days) after the beginning of the disease, thereafter only ICP of mild forms of ICM were recorded. In nine patients, the biopsy examination was repeated and the histological picture of the lesion changed in all cases. When the second biopsy was performed 11-31 months after the 1st one (7 samples), all myogenic features i.e. picture of simple or necrotizing myopathy disappeared and either recovery with normal histopathological finding (five patients) or a picture of a persistent neurogenic lesion (two patients) was found. On the other hand, electrophysiological evidence of chronic denervation was recorded in all seven patients and did not reflect the clinical improvement of the patients condition. |
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