Publication details
HFE C282Y gene variant is a risk factor for the progression to decompensated liver disease in chronic viral hepatitis C subjects in Czech population
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Hepatology Research |
| MU Faculty or unit | |
| Citation | |
| Field | Endocrinology, diabetology, metabolism, nutrition |
| Keywords | hepatitis; HFE; iron; polymorphism |
| Description | Aims: To determine the prevalence of selected HFE polymorphisms (C282Y, H63D and S65C) among patients with chronic viral hepatitis B and C and to investigate their role in the progression of liver disease. Subjects and methods: A total of 207 subjects with chronic B or C viral hepatitis and 243 healthy controls were enrolled in the case control study. Cases were further classified according to the clinical stage of liver disease into three groups: (A) virus carriers, (B) compensated resp. (C) decompensated liver disease. HFE polymorphisms were detected by PCR-based methodology. Fisher exact, chi-square and Kruskal-Wallis tests were used to test for differences in variables studied between groups. Haplotypes were inferred in silico and their distribution compared by permutation test. Modified survival (time-to-event) analysis was used to test for the differences in the progression to the decompensated liver disease in carriers of C282Y wild-type vs. mutated genotypes. Results: The frequency of HFE genotypes, alleles and haplotypes differed neither between HBV nor HCV patients vs. controls. In HCV subjects (i) the frequency of the 282Y allele was significantly higher in the (C) group compared to (B) group (12.5 vs. 2.2%, respectively, P=0.002, Fisher exact test), and (ii) carriers of the 282Y mutation exhibited significantly faster progression to decompensated liver disease than wild-type carriers (P=0.044, log-rank test). Conclusion: Carriage of the minor of the HFE C282Y polymorphism is associated with decompensated liver disease and its earlier onset in the subjects with chronic viral hepatitis C in Czech population. |
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