The effect of perphenazine on transient outward potassium current in rat ventricular myocytes

• Authors: BÉBAROVÁ Markéta; MATEJOVIČ Peter; PÁSEK Michal; RAČKAUSKAS Gediminas; ŠIMURDOVÁ Milena; ŠIMURDA Jiří; NOVÁKOVÁ Marie
• Year of publication: 2006
• Type: Article in Periodical
• Magazine / Source: Analysis of Biomedical Signals and Images
• MU Faculty or unit: Faculty of Medicine
• Field: Physiology
• Keywords: perphenazine; transient outward current; rat ventricular myocytes
• Description: Perphenazine blocks transient outward potassium current Ito in a concentration-dependent manner by decreasing its amplitude and accelerating the apparent Ito-inactivation.

Related projects

• Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart
• Early diagnostics and treatment of cardiovascular diseases