Publication details

Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients

Authors

ŠPINAROVÁ Lenka ŠPINAR Jindřich VAŠKŮ Anna PÁVKOVÁ GOLDBERGOVÁ Monika LUDKA Ondřej TOMANDL Josef VÍTOVEC Jiří

Year of publication 2008
Type Article in Periodical
Magazine / Source Experimental and Molecular Pathology
MU Faculty or unit

Faculty of Medicine

Citation
Field Cardiovascular diseases incl. cardiosurgery
Keywords Genetics;cytokines;chronic hear failure;stratification
Description Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients. Patients with ischemic heart disease (IHD) and previous MI showed a difference in the distribution of genotype G8002A for endothelin-1: allele G 0.718 and A 0.282 vs those without MI: allele G 0.882 and A 0.118, (p < 0.05). Patients with IHD and DM had allele G in 0.67 and A 0.33, while those without DM had allele G in 0.790 and A in 0.209 (p < 0.03). Patients with IHD and concomitant PAD had allele G in 0.718 and A in 0.282 vs those without PAD allele G in 0.882 and A in 0.118 (p < 0.0004). Patients with dilative cardiomyopathy (DCMP) showed no differences in genotype G8002A and presence of DM or PAD. It might be speculated that in the case of endothelin-1 and TNF alpha in CHF the genetic determination is not important, and plasma concentrations are influenced more by the disease severity. Ischemics with previous MI, concomitant DM or PAD showed more frequently allele A and less often allele G than those without these diseases. A genotype with allele A is associated with higher risk of concomitant diseases.
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