Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation

• Authors: BÉBAROVÁ Markéta; 0´HARA Tom; GEELEN Jan; JONGBLOED Roselie; TIMMERMANS Carl; ARENS Yvonne; RODRIGUEZ Luz-Maria; RUDY Yoram; VOLDERS Paul
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: American Journal of Physiology - Heart and Circulatory Physiology
• MU Faculty or unit: Faculty of Medicine
• Field: Cardiovascular diseases incl. cardiosurgery
• Keywords: Brugada syndrome; mutation; patch clamp; cell lines; arrhythmogenesis
• Description: Our data may explain ST-segment elevation on the basis of massive transmural voltage gradients during early repolarization. Reentry-based tachycardia could be evoked during conditions that further exaggerate conduction block in this Brugada phenotype.