Behavioural sensitization to methamphetamine affects expression of dopamine D1 receptors in mouse midbrain

• Authors: LANDA Leoš; JURAJDA Michal
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: The International Journal of Neuropsychopharmacology
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: behavioural sensitization; methamphetamine; dopamine D1 receptors; mice
• Description: The behavioural part of experiment showed stimulatory influence of methamphetamine (Met) after the acute administration and development of sensitization to Met after repeated treatment. Real-time PCR results showed increased D1 mRNA expression after Met first dose followed by further increase after the last dose of repeated treatment.

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