Publication details

Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis

Authors

BENEŠOVÁ Yvonne VAŠKŮ Anna ŠTOURAČ Pavel HLADÍKOVÁ Magdaléna BERÁNEK Michal KADAŇKA Zdeněk NOVOTNÁ Hana BEDNAŘÍK Josef

Year of publication 2008
Type Article in Periodical
Magazine / Source Journal of Neuroimmunology
MU Faculty or unit

Faculty of Medicine

Citation
Field Neurology, neurosurgery, neurosciences
Keywords gene polymorphism; matrix metalloproteinases; multiple sclerosis
Description We investigated the association of matrix metalloproteinase-9 (-1562C/T, +279R/Q) and matrix metalloproteinase-2 (-1575G/A, -1306C/T) gene polymorphisms with multiple sclerosis (MS) susceptibility, gender differences and disability in 244 patients and 132 healthy subjects. A significant decrease of the -1562T allele carriers in MS patients compared to controls (Pa=0.01, Pacorr=0.05) in -1562C/T MMP-9 gene polymorphism was found, (odds ratio (OR) -0.58, 95% confidence interval (CI):0.38-0.89). Significant differences were also demonstrated between female patients and healthy females (Pa=0.01, Pacorr=0.05), (OR-0.53, 95% CI:0.32-0.86). Other polymorphisms were not associated either with MS susceptibility or with phenotype of the disease. No association with disability was found.

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