HAPLOTYPE OF FOUR MMP2 GENE PROMOTER POLYMORPHISMS AS PROTECTION VARIANT FOR ISCHEMIC HEART DISEASE AHEAD OF PROGRESSION TO HEART FAILURE

• Authors: PÁVKOVÁ GOLDBERGOVÁ Monika; POLOCZEK Martin; PAŘENICA Jiří; ŠPINAROVÁ Lenka; GROCH Ladislav; ŠPINAR Jindřich; VAŠKŮ Anna
• Year of publication: 2008
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: The study detected differences in genotype distributions and/or alelle frequences of MMP2 -790G/T polymorphism between patients with chronic heart failure on base of IHD and IHD patients (Pg=0.001, OR=3.07; Pa=0.01). Further, highly significant association in haplotype frequences was observed between chronic heart failure on base of IHD and IHD patients (Pg=0.0014), with higer prevalence of GCGC haplotype within the CHF group (OR=29,51; P=0.000001).

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