Project information
Complex estimation of relation of MMP-1,2,3,9,TIMP-1 and ACE polymorphisms to left ventricuzlar remodelation and to medium-term prognosis after acute infarct myocardum with ST elevation treated by primary PCI
- Project Identification
- NR9356
- Project Period
- 1/2007 - 12/2009
- Investor / Pogramme / Project type
-
Ministry of Health of the CR
- Ministry of Agriculture R&D Programme
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- acute infarct myocardum, gene, polymorphism, serum levels
- Cooperating Organization
-
University Hospital Brno-Bohunice
- Responsible person MUDr. Martin Poloczek
- Responsible person MUDr. Otakar Boček
- Responsible person MUDr. Petr Jeřábek
- Responsible person MUDr. Petr Neugebauer, Ph.D.
- Responsible person prof. MUDr. Mgr. Jiří Pařenica, Ph.D.
Assesment of genetic variability of MMP, TIMP and ACE genes in respect in respect to acute infarct myocardum and its intermediate phenotype, inclusive of the analysis of selected serum levels.
Publications
Total number of publications: 8
2011
-
Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor?
Physiological Research, year: 2011, volume: 60, edition: 1
-
Relationship between high aortic pulse pressure and extension of coronary atherosclerosis in males
Physiological Research, year: 2011, volume: 60, edition: 1
2010
-
RXRA introne polymorphism and ABO blood groups in chronic heart failure
Cent. Eur. J. Biol, year: 2010, volume: 6, edition: 5
2009
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Association of TIMP-2 intron polymorphism with LV systolic dysfunction in acute MI
Year: 2009, type: Conference abstract
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Assocition of the ACE gene I/D polymorphism and left myocardial systolic dysfunction in patients with acute ST elevations myocardial infarction treated by primary PCI
Year: 2009, type: Conference abstract
-
Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI
Year: 2009, type: Conference abstract
2008
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HAPLOTYPE OF FOUR MMP2 GENE PROMOTER POLYMORPHISMS AS PROTECTION VARIANT FOR ISCHEMIC HEART DISEASE AHEAD OF PROGRESSION TO HEART FAILURE
Year: 2008, type: Conference abstract
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Protection Variant of MMP2 Polymorphism Haplotype - A New Prognostic Factor for Ischemic Heart Disease Ahead of Progression to Heart Failure?
Year: 2008, type: Conference abstract