The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo.

• Authors: BRYJA Vítězslav; ANDERSSON Emma R.; SCHAMBONY Alexandra; ESNER Milan; BRYJOVÁ Lenka; BIRIS Kristin K.; HALL Anita C.; KRAFT Bianca; ČAJÁNEK Lukáš; YAMAGUCHI Terry P.; BUCKINGHAM Margaret; ARENAS Ernest
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: : Molecular Biology of the Cell
• MU Faculty or unit: Faculty of Science
• Field: Genetics and molecular biology
• Keywords: non-canonical Wnt signalling; Lrp5/6; mouse; Xenopus
• Description: Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here, we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling using biochemical approach, and mouse and Xenopus in vivo models. We provide evidence that the extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during Xenopus and mouse development in vivo.

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