Publication details
2-Fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | World Intellectual Property Organization |
| State | United States of America |
| Patent's number | WO 2009/070567 A1 |
| Description | Title compds. represented by the formula I [wherein R3 = H, (cyclo)alkyl, alkynyl, etc.; R5, R7 = independently H, (amino)alkyl, aryl, etc.; R6 = H, halo, (hetero)aryl, etc.; and pharmaceutically acceptable salts, solvates,esters prodrugs or stereoisomers thereof] were prepd. as protein kinase inhibitors (no data). For example, II was provided in a multi-step synthesis starting from the reaction of 1-Boc-piperidine-3-carboxylic acid with Meldrum's acid. Pyrazolo[1,5-a]pyrimidine-based inhibitors of various kinase, compns. including the inhibitors, and methods of using the inhibitors and inhibitor compns. are described. The invention also provides for methods of making CDK-2 or CHK-1 inhibitor compds., methods of inhibiting CDK-2 or CHK-1, and methods for treating disease or disease symptoms. |