Publication details
Do alpha 5-containing GABA(A) receptors have a role to play in ethanol reward?
Authors | |
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Year of publication | 2004 |
Type | Article in Periodical |
Magazine / Source | Alcoholism: Clinical and Experimental Research |
MU Faculty or unit | |
Citation | |
Field | Pharmacology and pharmaceutical chemistry |
Keywords | ethanol addiction; GABA receptor |
Description | We tested this hypothesis that GABA(A) receptors containing alpha 5 subunits mediate the rewarding effects of ethanol. Data obtained in a mouse model of ethanol self-administration show, that alpha 5 subunits may not be essential to signaling ethanol reward. Nevertheless, inverse agonists acting at alpha 5-containing receptors reduced ethanol self-administration. |