Expression of CD27 on plasma cells in monoclonal gammopathies

• Authors: KOVÁŘOVÁ Lucie; BUREŠOVÁ Ivana; SUSKÁ Renata; ZARBOCHOVÁ Pavla; HÁJEK Roman
• Year of publication: 2009
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Citation: KOVÁŘOVÁ, Lucie, Ivana BUREŠOVÁ, Renata SUSKÁ, Pavla ZARBOCHOVÁ and Roman HÁJEK. Expression of CD27 on plasma cells in monoclonal gammopathies. In Analytical cytometry V. 2009. ISBN 978-80-254-2561-5.
• Description: Multiple myeloma (MM) is characterised by a clonal expansion of neoplastic plasma cells (PC). These PCs are mostly CD19-CD56+, but in a small group of patients clonal CD19+ PCs occur. The aim of this study was to analyse expression of CD27 on CD19+ PCs in different groups of MM patients and to prove that CD27 can be routinely used to confirm polyclonality of CD19+ PCs. In group of 5 patients with clonal CD19+ PCs was the correlation between median of CD19+CD56- PCs and CD19+CD27+ PCs significantly lower (0.36) than in group 55 patients with polyclonal CD19+ PCs (0.96). In our hands expression of CD27 on CD19+ PCs can discriminate between clonal and polyclonal CD19+ PCs and thus can be potentially used instead of labour intensive light chains assessment.

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