Electrochemical behavior of DNA and RNA heptamers at a mercury electrode

• Authors: TRNKOVÁ Libuše; BALCAROVÁ Zdeňka; NEPLECHOVÁ Kamila
• Year of publication: 2009
• Type: Article in Proceedings
• Conference: Chemické Listy 103, Modern Electroanalytical Methods 2009
• MU Faculty or unit: Faculty of Science
• Field: Electrochemistry
• Keywords: heptamer; electrochemistry
• Description: Hairpins play an important role in many biological processes, including the triplet repeat expansion associated with neurodegenerative diseases. They also form a part of several anomalous DNA or RNA arrangements as triplexes or quadruplexes. The shortest and most stable hairpin yet characterized is formed by the DNA heptamer d(GCGAAGC). This sequence is found in replication origins of herpes simplex virus, in a promoter region of an Escherichia coli heat-shock gene, and in rRNA genes. We studied the shortest hairpin d(GCGAAGC) and r(GCGAAGC) and several other hairpins whose loop sequence is different.

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