Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status

• Title in English: Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status.
• Authors: HUBLAROVÁ Pavla; HRSTKA Roman; ROTTEROVÁ Pavla; ROTTER Leopold; ČOUPKOVÁ Marie; BADAL Vinay; NENUTIL Rudolf; VOJTĚŠEK Bořivoj
• Year of publication: 2009
• Type: Article in Periodical
• Magazine / Source: International Journal of Gynecologic Cancer
• MU Faculty or unit: Faculty of Medicine
• web: http://www.pubmed.gov
• Field: Other medical specializations
• Keywords: cervix; cervical intraepithelial neoplasia; HPV16; E6 gene; promoter methylation
• Description: Human papillomavirus (HPV) infection is the most important risk factor for development of CIN and cervical cancer. We analyse HPV16 E6 gene promoter methylation. Incidence of HPV16 significantly differed (P<0.001,chi-square test of Pearson). Methylation was detected and statistical significant differencies were found (P<0.001; Pearsons chi-square test). Methylation of the E6 gene promoter is predictive biomarker for cervical cancer progression.

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