Publication details
Lack of Population Diversity in Human Embryonic Stem-Cell Lines
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | New England Journal of Medicine |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | human embryonic stem cell; population diversity |
| Description | We determined the genetic ancestry of large collection of stem-cell lines. We have found that widely distributed stem-cell lines lack population diversity and that none of these lines derive from populations with recent African ancestry. Efforts to derive and disseminate new stem-cell lines should now emphasize underrepresented pupulations, to allow researchers to assess the extent to which the ancestry of stem-cell lines influences diesease models, cellular therapies, and drug screening with the use of stem cells. |
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