Association of TIMP-2 intron polymorphism with LV systolic dysfunction in acute MI

• Authors: PÁVKOVÁ GOLDBERGOVÁ Monika; PAŘENICA Jiří; KALA Petr; POLOCZEK Martin; ŠPINAR Jindřich; LAUŠOVÁ Jarmila; VAŠKŮ Anna
• Year of publication: 2009
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in cardiovascular diseases. This study was undertaken to investigate the intron poymorphism in gene for matrix metalloproteinase inhibitor TIMP2 in acute myocardial infarction with ST elevations. Population and methods: A total of 550 patients with acute MI with ST elevations treated by primary PCI and control group of 200 subjects were available for study. The TIMP_2 A/G intron polymorphism in position 10778369 (rs8176329) was detected by TaqMan SNP genotyping. LVEDP was measured before primary PCI. Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to median of ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA).

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