Publication details

Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI

Authors

PAŘENICA Jiří PÁVKOVÁ GOLDBERGOVÁ Monika KALA Petr POLOCZEK Martin MAŇOUSEK Jan ČERMÁKOVÁ Zdena TOMAN Ondřej TOMČÍKOVÁ Daniela ŠPINAR Jindřich

Year of publication 2009
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Myocardial infarction (MI) following reparative processes include inflammatory cell infiltration, activation of matrix metalloproteinases (MMPs – family of Zn-dependent endopeptidases), extracellular matrix remodeling and scar formation. The goal of the study was the exploration of MMP-2 serum activity early after MI and its assocition with signs of acute heart failure (AHF), left ventricle systolic dysfunction, with hospital mortality and oxidative stress. Population and methods: A total of 311 patients (75% male, age 62,7 years) with acute MI with ST elevations treated by primary PCI (without AHF – 220 pts, with AHF 91 pts). Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA). MMP-2 (value B), Troponin I, BNP, NT-proBNP, malondialdehyd (MDA), TNF-alfa, vitamine A and E, uric acid were eveluated 24 hours after chest pain occurance. MMP-2 (value A) was also evaluated during admission before primary PCI, we count difference of MMP-2 (value A-B) during admission and after 24 hours. Left ventriculography was done and dP/dt/P and LVEDP was measured before primary PCI.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info