Publication details
Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex
Authors | |
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Year of publication | 2010 |
Type | Article in Periodical |
Magazine / Source | Chemistry - An Asian Journal |
MU Faculty or unit | |
Citation | |
Web | http://dx.doi.org/10.1002/asia.200900655 |
Field | Biophysics |
Keywords | DNA structures; interstrand crosslinks; molecular modeling; NMR spectroscopy; platinum |
Description | An unusual G6G11 interstrand crosslink is formed by spontaneous rearrangement of the canonical G5G6 intrastrand crosslink generated from the DNA duplex d(CCTTG5G6T7C8TC)-d(G11AGACCAAGG) and Pt(S,S-di-aminocyclohexane)2+ (the enantiomer of the antitumor drug oxaliplatin). The final product provides a rare example of intramolecular self-intercalation of DNA. |
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