Publication details

Exploring the 3D structure of the N-acetylglucosaminyltransferase V

Authors

KOZMON Stanislav TVAROŠKA Igor

Year of publication 2009
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description In the present study, we have attempted to build model of the GnT-V 3D-structure. Unfortunately, it is not clear to which GT family GnT-V belongs, therefore, we used one structure from the GT-A family and one structure from the GT-B one as structure templates. Selected structures had the best primary sequence alignment with GnT-V minimal catalytic domain. We have chosen structure of Core2 transferase (2GAM) as the representative of the GT-A family and MurG transferase (1NLM) as the representative of the GT-B family, respectively. We made several alignments employing different algorithms, namely with Blosum62, 120PAM or 3D-PSSM. We obtain altogether 10 models of the GnT-V structure.

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