Informace o publikaci
Exploring the 3D structure of the N-acetylglucosaminyltransferase V
| Autoři | |
|---|---|
| Rok publikování | 2009 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | In the present study, we have attempted to build model of the GnT-V 3D-structure. Unfortunately, it is not clear to which GT family GnT-V belongs, therefore, we used one structure from the GT-A family and one structure from the GT-B one as structure templates. Selected structures had the best primary sequence alignment with GnT-V minimal catalytic domain. We have chosen structure of Core2 transferase (2GAM) as the representative of the GT-A family and MurG transferase (1NLM) as the representative of the GT-B family, respectively. We made several alignments employing different algorithms, namely with Blosum62, 120PAM or 3D-PSSM. We obtain altogether 10 models of the GnT-V structure. |