Funkční deficit pentózového cyklu jako důsledek abnormálního metabolizmu thiaminu ve vztahu k progresi diabetické nefropatie a k mortalitě

• Title in English: Functionally deficient pentose phosphate pathway as a result of abnormal thiamine metabolism in relation to the progression of diabetic nephropathy and mortality
• Authors: PÁCAL Lukáš; TOMANDL Josef; SVOJANOVSKÝ Jan; KRUSOVÁ Darja; ŠTĚPÁNKOVÁ Soňa; OLŠOVSKÝ Jindřich; BĚLOBRÁDKOVÁ Jana; TANHÄUSEROVÁ Veronika; TOMANDLOVÁ Marie; ŘEHOŘOVÁ Jitka; SMRŽOVÁ Jana; HERTLOVÁ Miluše; MUŽÍK Jan; KAŇKOVÁ Kateřina
• Year of publication: 2010
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: Pentose phosphate pathway (PPP) represents a potentially protective pathway in hyperglycemia. Transketolase is the key enzyme of PPP. We aimed to find out whether parameters of thiamine metabolism can influence progression of diabetic nephropathy (DN) and morbidity of patients with DN.

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