Publication details

YEAST PATHOGENS: THE CYTOSKELETON AND THE CELL WALL AS TARGETS FOR ANTIFUNGALS-INVITED LECTURE

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Authors

KOPECKÁ Marie SVOBODA Augustin YAMAGUCHI Masashi

Year of publication 2010
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description We identified the cytoskeleton in Cryptococcus neoformans, Aureobasidium pullulans, Fellomyces fuzhouensis, Cryptococcus laurentii and Malassezia pachydermatis. The cytoskeleton is involved in budding, bud-fission, hyphal growth and conidiogenesis of human yeast and fungal pathogens. We investigated the cytoskeleton as a potential target for inhibition of morphogenesis using microtubule and actin inhibitors. All microtubule inhibitors were effective, but clinical ones only transiently and resistant cells originated. Cytochalasins were not effective. Latrunculin A inhibited budding, fission, hyphal growth, conidiogenesis. The most efficient inhibition was reached by combining the microtubule and actin inhibitors (Kopecká M.,Gabriel M., Chemotherapy 2009;55:278-286). Our study provided new results of the basic research on the cytoskeleton as a new potent target for inhibition of yeast pathogens that may show the way to a new antifungal strategy.
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