Publication details

Lucentis v léčbě věkem podmíněné makulární degenerace

Title in English Lucentis in treatment of age related macular degeneration
Authors

KOLÁŘ Petr VYSLOUŽILOVÁ Daniela VIŽĎOVÁ Drahomíra POLANSKÁ Veronika

Year of publication 2009
Type Article in Proceedings
Conference Sborník 5. bilaterálního Česko-Slovenského oftalmologického sympózia
MU Faculty or unit

Faculty of Medicine

Citation
Field ORL, ophthalmology, stomatology
Keywords age related macular degeneration; choroidal neovascular membrane; vascular endothelial growth factor; ranibizumab
Description The authors evaluated results achieved with the use of ranibizumab (Lucentis) for wet age-related macular degeneration (AMD). Ranibizumab (Lucentis, Novartis) is an antagonist of vascular growth factor (VEGF), approved for intraocular injection in the wet form of age-related macular degeneration (AMD). Ranibizumab in our department is used to treat patients with occult, minimally classic or predominantly classic subretinal neovascular membrane (CNV) in the subfoveal location. Patients included in the study had 3 applications ranibizumab every 1 month (loading phase), followed by applications as needed - the maintenance phase (ie, if a decrease visual acuity by more than 5 ETDRS letters, or edema will increase by more than 100 mi). Our 9-month results demonstrate the ability of Lucentis to stop the progression of wet AMD and preserve visual acuity in most patients. Improvement of visual acuity is possible in particular by the treatment of patients in earlier stages of disease. To maintain profit visual acuity to be a monthly monitored during the maintenance phase of treatment.

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