Publication details
Kombinovaná léčba v léčbě retinální angiomatózní proliferace (Macugen a PDT s Visudynem)
| Title in English | Combined treatment in treatment of retinalangiomatous proliferation (Macugen and PDT with Visudyne) |
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| Authors | |
| Year of publication | 2009 |
| Type | Article in Proceedings |
| Conference | Sborník 10. Vejdovského olomouckého vědeckého dne |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | age related macular degeneration; combined therapy; photodynamic therapy; anti VEGF |
| Description | The main task of this study was to evaluate the effectiveness of combination therapy (Macugen + PDT with Visudyne) in the treatment of retinal angiomatous proliferation. Conventionally used in monotherapy (PDT with Visudyne, or anti-VEGF) have not a good therapeutic effect. Combined PDT with Visudyne and anti-VEGF therapy may improve the therapeutic effect. RAP is divided into 3 stages. Stage I - intraretinal neovascularization: intraretinal neovascularization (IRN) begins in the deep capillary plexus outside the fovea center. During development, the most typically spread in the vertical, ie between the outer and inner limiting membrane of the retina. IRN spreading toward the parties is initially characterized. Biomicroscopically we observed dilation of capillary networks with a large nourishing blood vessel and intraretinal haemorrhage. Stage II - subretinal neovascularization: This stage is diagnosed if the level of IRN shifts between photoreceptors and RPE. In this area, creating an ablation with a corresponding neuroretinal edema. Intraretinal haemorrhages are more evident than in the previous stage. Stage III - CNV: In stage III, already diagnosed typical CNV in combination with vascularised RPE ablation. The end stage is then visible disciform scar. Combining PDT with Visudyne and Macugen intravitreal injection is an appropriate choice for the treatment of RAP. This process is not accompanied by complications. Visual acuity of patients at the end of follow-up period was at the same level as at the beginning of therapy. |