Publication details
Věkem podmíněná makulární degenerace (etiopatogeneze, diagnostické a terapeutické možnosti)
| Title in English | Age related macular degeneration (etiopathogenesis, diagnostic and therapeutic possibilities) |
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| Authors | |
| Year of publication | 2007 |
| Type | Article in Proceedings |
| Conference | Sborník 8. Vejdovského olomouckého vědeckého dne |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | age related macular degeneration; choroidal neovascular membrane; fluorescence angiography; optical coherence tomography |
| Description | Age-related macular degeneration (AMD) is the most common cause of severe vision loss in developed countries in the population over 65 years of age. In a study of aetiopathogenesis of AMD occurred in the last 10 years a significant shift. It was found that the influence of age is to reduce the number of cells of the retinal pigment epithelium (PE). This leads to a reduction in the number of melanosomes, which have a protective effect against the toxic effects of blue light in particular. Due to the increasing age is the accumulation of lipofuscin, protein aging, the activation of free oxygen radicals leads to accelerate the process of apoptosis (natural cell death). |