Publication details
Chronic treatment with haloperidol changes expression of sigma-1 receptor in rat heart.
| Authors | |
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| Year of publication | 2010 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | The effects of sigma receptor ligand haloperidol on expression of sigma-1 receptor after three weeks treatment with this drug were studied in individual parts of the heart - both atria and ventricles. The samples were stored at -80C until PCR specific for the sigma-1 receptor was carried out. Cycloidin was used as a housekeeper gene control for semi-quantitative evaluation of PCR. All PCR products were analyzed on 2% agarose gels. Intensity of individual bands was evaluated by measuring the optical density per mm2 and compared relative to CYCLO mRNA. |
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