Publication details
The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Angewandte Chemie International Edition |
| MU Faculty or unit | |
| Citation | |
| Web | http://onlinelibrary.wiley.com/doi/10.1002/anie.200906828/abstract |
| Field | Biophysics |
| Keywords | conformation analysis;cytotoxicity;microtubules;NMR spectroscopy;tubulysin |
| Description | Bound to be active: The solution structure of tubulin-bound tubulysin A is determined from transferred NOE data (see picture; blue N, red O, yellow S, green C), and this bioactive conformation is compared to the unbound conformation. The binding site on tubulin is examined on the basis of the interligand NOEs observed between epothilone A and tubulysin A in the presence of tubulin. |
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