Publication details
Effect of polyunsaturated fatty acids on the reactive oxygen and nitrogen species production by RAW 264.7 macrophages
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | European Journal of Nutrition |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.ncbi.nlm.nih.gov/pubmed/19784538 |
| Field | Immunology |
| Keywords | Polyunsaturated fatty acids; Reactive oxygen species; Reactive nitrogen species; RAW 264.7 cells; Chemiluminescence |
| Description | High concentrations of PUFAs of both omega-3 and omega-6 groups can inhibit ROS and RNS formation by stimulated macrophages. The expression of iNOS can also be inhibited. This effect, together with the absence of antioxidant activity and cytotoxic properties, indicates that PUFAs can participate in the regulation of enzymes responsible for reactive species production. |