Zvýšení toxicity perzistentních organických polutantů v přítomnosti huminových látek

• Title in English: Enhancement of toxicity of various persistent organic pollutants after interaction with dissolved humic substances
• Authors: BITTNER Michal; NOVÁK Jiří; GIESY John P.; HILSCHEROVÁ Klára
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Bulletin VÚRH Vodňany
• MU Faculty or unit: Faculty of Science
• Field: Water pollution and control
• Keywords: humic substances; dioxin-like toxicity; aryl hydrocarbon receptor
• Description: Humic substances (HS) are ubiquitous natural products of natural organic matter decomposition. We describe in vitro effects of binary mixtures of various HS samples with model compounds from different classes of environmental pollutants in H4IIE-luc cell line. Six out of 12 HS samples activated AhR even at environmentally relevant concentrations (17 mg.l-1), but did not induce full AhR-activation even at excessive concentration. In simultaneous exposure of H4IIEluc cells to HS (17 mg.l-1) and each of the model compounds, TCDD (1.2 pM), PCB126 (0.01nM), benzo[a]pyrene (40nM), benzo[a]anthracene (240nM), dibenz[a,h]anthracene (1nM) and fluoranthene (40,000nM), either significant additive or facilitative effects were observed when compared to the activities of the single model pollutants. No negative interactions, due to possible sorption of model compounds to HS, were observed.

Related projects

• Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
• Interaction of humic substances and UV-VIS irradiation with dioxin-like environmental pollutants
• Centrum pro výzkum toxických látek v prostředí