Publication details
Genetika atopickej dermatitídy
| Title in English | Genetics of Atopic Dermatitis |
|---|---|
| Authors | |
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Česko-slovenská dermatologie |
| MU Faculty or unit | |
| Citation | |
| Field | Dermatovenerology |
| Keywords | atopic dermatitis; genetic background; genetic studies |
| Description | Atopic dermatitis (AD) is a multifactorial disease. In its etiopathogenesis play role various factors including: genetic and environmental factors, metabolic and immunologic mechanisms and defect of epidermal barier. Genome screenings of families with AD have implicated chromosomal regions that overlap with other skin diseases and with inflammatory and autoimmune diseases. These, together with candidate gene studies, provide novel insights into the pathogenesis of AD. Recent genetic advances with high-throughput methods for gene identification, such as DNA microarrays and whole-genome genotyping, will help further dissect this complex trait. This will aid disease-defining criteria and more targeted therapies for AD. |