Induction by lenalidomide and dexamethasone combination increase CD4 and CD8 regulatory cells of newly diagnosed multiple myeloma patients

• Authors: MUTHU RAJA Karthick Raja; PLÁŠIL Martin; KOVÁŘOVÁ Lucie; ŠTOSSOVÁ Jana; HÁJEK Roman
• Year of publication: 2011
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: Naturally occurring regulatory cells play an active role in maintaining immune system homeostasis. In various hematological malignancies and solid tumors it was proved that T regulatory cells (Tregs) were increased and functionally active in abrogating immune responses. Few studies documented the expansion of Tregs in the relapsed multiple myeloma (MM) patients after lenalidomide and dexamethasone treatment. Aims. To screen the frequency of regulatory (CD4 and CD8 Tregs) and suppressor (Ts) cells between pre- and postinduction cycle by lenalidomide plus dexamethasone combination in newly diagnosed MM patients. In summary, regulatory cells were increased after induction with lenalidomide and dexamethasone combination in newly diagnosed MM patients. This observation should be taken into consideration to efficiently improve the immuno-stimulatory effects for MM patients.

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