Publication details
Biologická léčba nemalobuněčného karcinomu plic
| Title in English | Biological therapy for non-small-cell lung carcinoma |
|---|---|
| Authors | |
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Interní medicina pro praxi |
| MU Faculty or unit | |
| Citation | |
| Field | Other specializations of internal medicine |
| Keywords | non-small-cell lung carcinoma (NSCLC); biological therapy; prognostic factors; predictive factors |
| Description | The therapeutic outcomes in recent years have shown that the possibilities of conventional chemotherapy have been exhausted and other combinations of conventional cytostatic drugs are not expected to significantly prolong the survival of patients with NSCLC. Another option for these patients is a therapy targeted at cell signalling pathways and their modulation. This method of therapeutic intervention is referred to as biologically targeted therapy. Unlike conventional cytostatic treatment, biological therapy is an approach at the subcellular level. While manipulating the natural regulatory mechanisms controlling the metabolism, proliferation and migration of cancer cells, biological therapy uses low-molecular-weight agents, macromolecules as well as immune effector cells. The article deals with the biological therapy agents that have been approved for use in the Czech Republic. |