Publication details
Chirurgická léčba vitiliga transplantací nekultivovaných autologních melanocytů - naše studie
| Title in English | Surgical treatment of vitiligo of noncultivated autologous melanocytes transplantation – our experience |
|---|---|
| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Dermatologie pro praxi |
| MU Faculty or unit | |
| Citation | |
| Field | Surgery incl. transplantology |
| Keywords | vitiligo; surgical treatment of vitiligo; transplantation of autologous melanocytes |
| Description | Vitiligo belongs to the idiopathic disorders of skin pigmentation. Causal treatment is impossible for now and conservative treatment is ineffective with most patients. The surgical treatment can be effective with some patients with the history of ineffective conservative treatment. Many modifications of surgical treatment of vitiligo have apperared during the past few years, from transplantation of fullthickness skin grafts till transplantation of melanocytes expanded by cultivation. The surgical treatment of vitiligo by grafting of autologous noncultured melanocytes in fibrin glue which is used as a cell carrier is described in this article. This method is based on grafting of dermoepidermal graft and its incubation with trypsin. The skin cells suspension which is obtained after the trypsination is then applied into a mixture with fibrin glue onto depigmented vitiliginous skin previously dermabraded by CO2 laser. We used this method for treatment at 13 patients with stabile vitiligo, pigmentation was achieved at 5 patients. |