Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2

• Authors: PERNICOVÁ Zuzana; SLÁBÁKOVÁ Eva; KHARAISHVILI Gvantsa; BOUCHAL Jan; KRÁL Milan; KUNICKÁ Zuzana; MACHALA Miroslav; KOZUBÍK Alois; SOUČEK Karel
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Neoplasia
• MU Faculty or unit: Central European Institute of Technology
• Web: http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf
• Doi: http://dx.doi.org/10.1593/neo.11182
• Field: Genetics and molecular biology
• Keywords: CELLULAR SENESCENCE; IN-VIVO; DEPRIVATION THERAPY; SECRETORY PHENOTYPE; EPITHELIAL-CELLS; TUMORIGENESIS; FIBROBLASTS; EXPRESSION; GROWTH; PROLIFERATION
• Description: Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells.We propose that ADT may contribute to the development of androgen-independent prostate cancer through modulation of the tissue microenvironment by senescent cells.

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