Publication details

Současný vývoj cílené terapie nádorů oblasti hlavy a krku

Title in English Present stage of development in targeted therapy of head and neck cancer
Authors

MECHL Zdeněk BRANČÍKOVÁ Dagmar NEUWIRTHOVÁ Jana

Year of publication 2012
Type Article in Periodical
Magazine / Source Farmakoterapie
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords head and neck cancer; targeted therapy; cetuximab; tyrosine kinase inhibitors; angiogenesis inhibitors
Description The therapy of head and neck cancer has lately employed new irradiation techniques, induction chemotherapy, and most notably targeted (biological) therapy – in keeping with our growing understanding of the biology of signal pathways involved in the development and progression of tumours new therapies aimed at targets specific for tumour cells have been discovered and introduced. Of these therapies, best results in the treatment of head and neck cancers were obtained with cetuximab and its combination with radiotherapy and/or chemotherapy. Agents examined in this indication have also included monoclonal antibodies, e.g. panitumumab, tyrosine kinase inhibitors, or angiogenesis inhibitors; ongoing research is involved with other substances as well. In the future, biomarkers are urgently needed that would contribute to individualization and optimisation of therapy.

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