Publication details
Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Tissue Antigens |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1111/j.1399-0039.2011.01827.x |
| Field | Genetics and molecular biology |
| Keywords | association analysis; greying horse; melanoma; microsatellites; single nucleotide polymorphisms |
| Description | Melanoma is a common disease occurring in many horse breeds. As in all tumors its nature is complex, and specific genes were shown to be involved in the mechanisms of disease in humans as well as in various animal species (1). Grey horses, regardless of the breed, show high incidence of dermal melanomas. A mutation within the syntaxin 17 gene responsible for greying in horses was shown to be associated with occurrence of melanoma in grey horses but the association observed did not explain completely the variation observed (2). Other factors influencing the formation of melanoma thus must be involved. In this context, immunity-related genes can be considered as functional candidate genes. Old Kladruber grey horses were selected as a model for analyzing associations between microsatellite and candidate gene polymorphic markers and the presence of melanoma. Genetic diversity of this old, small, isolated and partially inbred population was characterized previously. |