Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation

• Authors: KREJČÍ Pavel; AKLIAN Anie; KAUCKÁ Markéta; ŠEVČÍKOVÁ Eva; PROCHÁZKOVÁ Jiřina; MIKOLKA Pavol; BÁLEK Lukáš; POSPÍŠILOVÁ Tereza; SPOUSTOVÁ Tereza; BRYJA Vítězslav; VESELÁ Iva; KOZUBÍK Alois; WEIS MaryAnn; PAZNEKAS W.A.; WOLF J.H.; GUTKIND J.S.; WILCOX W.A.; WNAG JABS E.; SALAZAR Lisa; MAŠEK Jan Kukla
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: Plos One
• MU Faculty or unit: Faculty of Science
• Doi: http://dx.doi.org/10.1371/journal.pone.0035826
• Field: Physiology
• Keywords: Receptor tyrosin kinase; Wnt/beta catenin; MAPK; LRP6
• Description: Receptor tyrosine kinase signaling cooperates with WNT/beta catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined. We describe a potent activation of WNT/beta catenin by FGFR2 FGFR3, EGFR and TRKA kinases, which is independent of the PI3K/Akt pathway and it depends on ERK-MAPK mediated phospohrylation of WNT co-receptor LRP6.

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