Publication details
QUANTUM DOTS AND THEIR INTERACTIONS WITH BIOMOLECULES
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Proceedings |
| Conference | XII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků. |
| MU Faculty or unit | |
| Citation | |
| Field | Biochemistry |
| Keywords | quantum dots;oligonucleotides;differential pulse voltammetry;prion protein |
| Description | Semiconductor quantum dots (QDs) coated with thioalkyl acid ligands are often used as probes and reporters for nucleic acid sensing, or protein sensing using aptamers, and are also potential vectors for gene delivery. In such applications, the interactions that potentially lead to the adsorption of oligonucleotides onto the surface of colloidal QDs are an important consideration. The interaction between Beta-sheet breaker prion protein and CdTe quantum dots (QDs) was studied by differential pulse voltammetry connected with adsorptive transfer stripping technique. Results showed that the electrochemical signals of prion protein were strongly quenched by CdTe QDs. This phenomenon can be considered as a first step of suggesting of a biosensor for determination of prions in real samples without a sample pre-treatment. |