Publication details
STUDY OF INTERACTION OF QUANTUM DOTS WITH METALLOTHIONEIN USING DIFFERENTIAL PULSE VOLTAMMETRY
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Proceedings |
| Conference | XII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků. |
| MU Faculty or unit | |
| Citation | |
| Field | Physical chemistry and theoretical chemistry |
| Keywords | quantum dots;fluorescent agent;cadmium;metallothionein;Brdicka reaction |
| Description | Quantum dots (QDs), are emerging as a new class of fluorescent agent for biochemical, medicinal or other purposes. QDs based on cadmium or else heavy metal composition can be risky for an organism. In the organism cadmium can be neutralized by protein metallothionein (MT). MT is cysteine rich and the chelation of other metals including essential zinc is well described. For the reason of high affinity of metallothionein to cadmium ions we attempted to develop an approach for study of possible interaction with (QDs). We prepared QDs with Cd-Te core and studied the interaction with Apo-MT, which was prepared from Cd immunized rabbit. For determination of Cd ions concentration in QDs we used method of differential pule voltammetry (DPV) and for study of complex of QDs with Apo-MT we used DPV – Brdicka s reaction. |