Publication details
Autologní léčba chondromalácie
| Title in English | Autologous therapy of chondromalatia |
|---|---|
| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Ortopedie |
| MU Faculty or unit | |
| Citation | |
| Field | Surgery incl. transplantology |
| Keywords | hyaline cartilage; growth factors; platelet-rich plasma |
| Description | The articular cartilage is a specialized connective tissue that supports and distributes the load and ensures a low-friction motion in joints. Such unique characteristics are provided by the highly organised extracellular matrix composed of fibrillar collagen, hydrated proteoglycans, and hyaluronic acid. Chondrocytes, the living component in articular cartilage, are responsible for maintaining the extracellular matrix in a balanced condition. Platelet-rich plasma is now widely used to treat several musculoskeletal soft-tissue lesions. Platelets contain many kinds of growth factors, such as platelet-derived growth factors, transforming growth factors, epidermal growth factor, and vascular endothelial growth factor. The use of these growth factors has been considered a way to manipulate the host healing response at the site of injury or degeneration, to facilitate the repair and remodelling of the chondral tissue. The state of the knowledge is discussed in the article. |