Publication details
Cardio-Ankle Vascular Index in Heterozygous Familial Hypercholesterolemia
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS |
| MU Faculty or unit | |
| Citation | SOŠKA, Vladimír, Petr DOBŠÁK, Ladislav DUŠEK, Kohji SHIRAI, Jiří JARKOVSKÝ, Marie NOVÁKOVÁ, Petr BRHEL, Jana ŠŤASTNÁ, Lenka FAJKUSOVÁ, Tomáš FREIBERGER and Tomoyuki YAMBE. Cardio-Ankle Vascular Index in Heterozygous Familial Hypercholesterolemia. JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS. TOKYO: JAPAN ATHEROSCLEROSIS SOC, 2012, vol. 19, No 5, p. 453-461. ISSN 1340-3478. |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | Atherosclerosis; Cardio-ankle vascular index; Familial hypercholesterolemia; Statins; Ezetimibe |
| Attached files | |
| Description | Aim: The cardio-ankle vascular index (CAVI) is a new non-invasive marker of arterial stiffness and atherosclerosis. The purpose of this study was to compare CAVI in patients with heterozygous familial hypercholesterolemia (FH) and in healthy controls. Methods: 82 FH subjects (27 males, 65 females), aged 53.7 +/- 13.6 years without clinical symptoms of cardiovascular diseases and 359 healthy controls (121 males, 238 females), aged 43.9 +/- 14.9 years, were examined. CAVI was measured using the system VaSera (R) 1500. Results: CAVI in FH patients was significantly higher (8.0 +/- 1.4) than in healthy subjects (7.5 +/- 1.3) p=0.002; however, age, sex and BMI adjusted CAVI did not differ significantly (p=0.061) between the FH group (7.5, CI: 7.3; 7.7) and control group (7.7, CI: 7.6; 7.7). Conclusion: The study showed no significant difference in CAVI between heterozygous FH and healthy controls. |
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